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A typical coven of witches; three young women performing magick by channeling the power of flame through a series of lit candles in the forest at night. Having been hunted and persecuted for centuries, witches typically travel at night and perform their rituals in hidden locales. (Art from the Darkness)

The Italians call them Strega. The Yoruba of West Africa call them Aje, meaning "mother." Where my mother was from, they called them Häxa. And here, we call them witch. Over the centuries, vampires have fought them and fought beside them, bedded them and burned them. Whether adversary or ally, they have been a force to be reckoned with.
The vampire Elijah Mikaelson describes witches.

A Witch is a human - typically a woman - endowed with occult powers by means of sorcery; typically harnessed either through a Faustian bargain with Lucifer or through the benign worship of the goddess Hecate - a religious movement known in contemporary times as Wicca or Paganism.

Another branch of witchcraft are humans who have been chosen by the goddess Gaia - Mother Nature herself - to serve and protect the Balance of Nature, otherwise called the Natural Order; namely the balance between life and death as well as battling demons and other malign forces.

Whichever branch a witch hails from, the magick of witchcraft is hereditary; typically passing from mother to child. Although magick is most prolific in women by virtue of their capacity to create and nurse life through their womb and breast, warlocks do exist and can sire young.